Cas No 1379686-29-9
Synonyms 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Formula C23H31ClN4O3S
Molucelar weight 479.03524
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal
substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols.
Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB. It also has good in vivo plasma/brain exposure.
The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression
of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters
circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.
The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and
adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced
obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target
the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30
days in different mouse models.
Hjtc (Xiamen) Industry Co., Ltd.
Xiamen Huayongjian Biotechnology Co., Ltd.
Contacts: June & Eason
Whatsapp:+8618206063252; +8618759200098
E-mail: eastern002@126.com;
eason_hjtc@126.com
Web site:https://www.steroidpowder-hjtc.com/
http://www.safeststeroid.com/
http://www.glassviallabels.com/
https://hjtc-printing.en.made-in-china.com/
Compounds were synthesized by reductive amination of 5-nitro-2-thiophenecarboxaldehyde with 4-chlorobenzylamine and sodium triacetoxyborohydride yielded the secondary amine. A second reductive amination with 1-Boc-pyrrolidine-3-carboxaldehyde yielded the tertiary amine. This compound was treated with trifluoroacetic acid to remove the Boc-protecting group, and then reacted with either ethyl chloroformate (SR9009) or pentyl isocyanate (SR9011) to give the desired products.
Item | Specification | Result |
Appearance | An odorless, almost white or white powder | pass |
Identificaton | The retention time of the major peak is
confirm to the RS |
pass |
Loss on Drying | Not more than 0.5% | 0.33% |
Assay(HPLC) | Not less than 99.0% | 99.59% |
Ignition residue | Not more than 0.1% | pass |
Heavy metal | Not more than 20 ppm | pass
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1. All powders are factory directly supplying.
2. Our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
3. Our products are of high quality at competitive prices. Free samples are available.
4. Well discreet packing. Fast and secure delivery by DHL, TNT, FedEx, HKEMS, UPS, etc.
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6. Exclusive customer service and 24/7 online timely and helpful after-sale service.
how to make order |
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Pre-sale service |
1.As for your every inquiries, we always reply timely and patiently. |
2. if you need we can offer provide you with COA , |
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1. By Express
------Suitable for under 50kg, Fast:3-7 days.
High cost; Door to door service. Easy to pick up the goods.
2. By Air
------Suitable for more than 50 kg, Fast:3-7 days,
High cost, airport to airport. professional broker needed.
3. By sea
------Suitable for more than 500kg. Slow: 5-45 days,
Low cost. Port to Port, professional broker needed.
1.Quality steroid powder and Favorable pricesFavorable prices
2.Newest and updated discreet ways
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4.One to one Exclusive customer service
5.Flexible and Untraceable payment terms
6.24/7 online helpful After-sale service
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1,Can i get some samples?
Yes, we can supply the free sample, but the shipping cost be paid by customer
2,How to confirm the Product Quality before placing orders?
We offer free sample,After you test the sample,you can know our quality.then place order.
3,Can you guarantee I can get my goods without any custom problem?
Yes, We have Reship Service.You can get your goods without any problem.
4,When you ship my order?
Normally within 2 to 3 days after confirming your payment
5,How about the quality guarantee period?
24 Months
6,How do you hide the products?.
Our shipping worker is very professional.They can pack various professional discreet package for hidding the products.