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Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue. It’s called MGF as IGF-IEa is a bit of a mouthful and harder to identify amongst the other IGF variants.What makes MGF special is its’ unique role in muscle growth. MGF has the ability to cause wasted tissue to grow and improve by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth. MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-1 receptor domain which, in turn, increases protein synthesis turnover; therefore, if used correctly it can improve muscle mass over time.

When you train, what happens to your muscles is they break down, the cells are damaged,muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant. The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die.As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair, if the cells are not repaired they die and your muscles get smaller and weaker. In muscle tissue, the pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.

Now, with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. In terms of dosages,200mcg bi-laterally is the very best choice of dosing in muscles trained.The only problem with MGF, and this is the reason I don’t like it, is that it has such a short half life,just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn’t been damaged. That’s why, for me personally, I think the best option is PEG MGF.

Nevertheless, MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is EXTREMELY anabolic.

PEG-MGF is a gene-spliced version of IGF-1, and quite simply a longer acting form of MGF. PEG-MGF holds up longer in the body and is said to have systematic effects (entire body) as well as local effects (site enhancement). Following a training session, PEG-MGF (IGF-1ec) defines muscle cells in trauma, puts them to work and tells them what to do. The result is the growth of new muscle cells, and an increase in the size of these cells through nitrogen retention and protein synthesis.

For starters, think about muscle growth like putting together a large hormonal puzzle. The picture gets clearer once we understand that the puzzle is made up of pieces like DHT, Testosterone HGH, IGF and MGF. Some of these hormones are expelled by the liver as a response to damaged muscle tissue. For example, growth hormone helps release insulin-like growth factor. One of the variants of insulin-like growth factor is MGF, better known as mechano growth factor. In the past, you had to depend on your body to produce IGF or MGF naturally, but not anymore. Now that scientists have been able to isolate and reproduce these peptide chains, bodybuilders and athletes can recover faster and increase hypertrophy like never before.

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It has been said that regular MGF is so short acting that it may be broken down too quickly even when used for site enhancement. By Pegylating MGF, it enhances its half-life making it more resistant to being metabolized that it can work on a systematic level as well as a local level.

Using PEG MGF on cycle or off cycle, you are going to experience recovery that is far superior to any generic peptide available. Just like normal peptides, remember that PEG MGF comes in the form of a white delicate powder that needs to be reconstituted with bacteriostatic water and kept in the refrigerator.

PEG MGF does not need to be systematically administered because of its long half-life (several days). It will circulate your body binding to the receptors where muscle tissue damage has taken place. Administration should be timed post workout or on recovery days when you plan on resting.

Since mechano growth factor is a variant of IGF-1, you do not want to use MGF pre-workout because it will have to fight for position with IGF-1 as they both try to bind to the same receptor. IGF-1 has a much stronger affinity to bind then MGF.

Rest days are the best way to get the most use out of PEG MGF, as you will have lower level of IGF-1 and the long lasting PEG MGF will have the ability to run the course of the body while you focus on recovery.

I have personally ran PEG MGF and administered into the quad regions after very long sessions where my quads were ripped to shreds. The recovery time and muscle growth in those areas was noticed after one week of use.

Duly noted was the recovery time after a 100+ mile ride. On the recovery day, I administered 200mcg of PEG MGF and rested. The following day muscles felt recovered and soreness was not present for the next training ride.

An insulin syringe needs to be used to inject subcutaneously or intramuscularly with a dose around 200-400mcg. Bilateral dosing can be used, but a single site administration will work just as well.

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