Factory wholesale AICAR raw powder - SR9011 Raw Powder CasNO.1379686-29-9 Factory Price UK USA Canada America Domestic Shipping – Hjtc

Product Name	SR9011
Synonym	3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
CAS	1379686-29-9
Assay	99%
Appearance	White powder
Standard	Enterprise Standard
Storage	Shading , Confined Preservation
Usage	For obesity, diabetes, dyslipidemia and cardiovascular disease
Molecular Fomular	C23H31ClN4O3S
Molecular Weight	479.04
Molecular Structure

 SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.

       Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

 SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.

       The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

  Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.

SR9011 alters the metabolic profile of skeletal muscle in a manner similar to the changes observed in animals that are endurance trained. Basically, the drug sends a signal to the muscle to tell it to modify its metabolism. Half of the mice studied showed improved running endurance in terms of both time and distance. What was clearly interesting was that a small, drug-like molecule could increase metabolic rate in skeletal muscle and increase exercise endurance SR9011 Not Just a “Diet” Pill.

There’s no way to sugarcoat it-though many have tried-maintaining a healthy weight can be difficult. Because it’s hard, many have tried “miracle” weight-loss pills and other quick fixes for something that ultimately requires a lifestyle change. Many over-the-counter diet and weigh-loss pills are unregulated and may contain dangerous ingredients. SR9011, however, isn’t like appetite suppressants, laxatives, or “fat blockers.” And you won’t find SR9011 in the ingredient lists of protein powders or exercise supplements.
 
       The difference between SR9009 and other diet pills is in its chemistry.SR9011 is not an appetitesuppressant-as many weight-loss drugs are-and directly works by increasing the metabolic rate of muscle. Your metabolism speeds up and slows down naturally during the day, meaning that sometimes food is used for energy and sometimes it’s stored as fat. By re-synching a dysfunctional metabolic clock, SR9011 ensures that food and excess fat are used as energy.
 
       SR9011 is one of a pair of compounds developed at TSRI by Burris and his team. The drug binds to Rev-erb,a natural protein in the body that influences lipid and glucose metabolism in the liver, inflammatory responses, and fat-storing cells. By binding to Rev-erb, SR9011 can kickstart metabolism with another pleasant side-effect: increased muscle strength.

1) Superior Quality And Competitive Price:
Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly.

2) Fast ,Safe And Well Disguised Delievery:

Well-trained and disciplined packing team and sufficient stock ensure the parcel can be delieveried to your hand fastly and safely by DHL, TNT, FedEx, HKEMS, UPS, etc.

3) Experienced In Exporting:
We have clients throughout the world. Products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries. Custome pass rate ≥99%

4) Flexible Payment Terms:
T/T,Western Union,Money Gram,Bitcoin. There will always be a term that is convient to you.

5) Warmhearted Customer Service And After-Sale Service:
The parcel’s photos and tracking numbers will be sent to you once it is prepared. Any of your questions would be solved as soon as possible.

Q1: Can I get some samples?
A: Sure, we offer free sample, you just need to pay the shipping cost.
 
Q2: How to make orders?
A: Please send inquiry to us, then we will do the offer. Payment via Western Union, Moneygram, Bank Account and Bitcoin. Then we will arrange shipping. After delivery we will offer tracking No..

Q3: Is the shipping 100% Guarantee?
A: Yes, we offer 100% Shipping Guarantee. If any seized parcel we will do resending. 

Q4: How to delivery?
A: Parcel will be shipped out in 3 working days after payment. Usually we use EMS, ePacket, Fedex, DHL, TNT and USA Domestic mixed shipping and so on. 
 
Q5: Is there any discount?
A:Yes. The price is negotiable. Just send us the items you need and the quantity. We will apply the best price and offer discount for you.
 
Q6: What is the Minimum order quantity?
A: Usually MOQ is 100g. But depends on the items and your requirements we also can do 10g, 20g, 30g or 50g.