Letrozole is also called Femara, it is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.Estrogen are produced by the conversion of androgens through the activity of the aromatase enzyme. Estrogen then bind to an estrogen receptor, which causes cells to divide.Femara prevents the aromatase from producing estrogen by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and Femara does not reduce production of mineralo- or corticosteroids.
Femara is a type II (non-steroidal) third generation aromatase inhibitor. Clinically it is used to treat postmenopausal women with either estrogen receptor positive or estrogen receptor unknown breast cancer. In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more.However, it's use and benefits are not limited to eliminating estrogen in women.For pre-contest bodybuilders, Femara is almost a necessity to eliminate water retention and achieve the ripped look necessary to compete in today's bodybuilding world. However, in my experience, it is only necessary to be used for the last 4-6 weeks, to eliminate excess estrogen and water retention. After using Femara I recommend staying away from any estrogen suppression for at least a month to try to normalize the body.
Test Items | Specification | Results |
Appearance | White or off-white crystaline powder | White crystalline powder |
Solubility |
Soluble in Chloroform;Soluble in ethanol when heated |
Conform |
ldentification |
Maximum absorption in wavelength of 240nmMinimum absorption in wavelength of 215nm | ConformConform |
Infrared spectrum should be in accordance the dominant peak of contrast | In accordance with the dominant peak of contrast | |
Melting points | 181℃-183℃ | 182℃ |
Related substances | ≤0.5% | 0.3% |
Single impurity | ≤0.3% | 0.2% |
Loss on drying | ≤1.0% | 0.8% |
Assay | ≥98.0% | 99.2% |
Conclusion | It conforms with Enterprise Standard |
Letrozol is used treat early breast cancer in women who have experienced menopause and who have had other treatments, such as radiation or surgery to remove the tumor. It is also used to treat early breast cancer in women who have experienced menopause and who have already been treated with a medication called tamoxifen (Nolvadex) for 5 years.Letrozol is also used in women who have experienced menopause as a first treatment of breast cancer that has spread within the breast or to other areas of the body or in women whose breast cancer has worsened while they were taking tamoxifen.
Inside, by 2.5 mg/day, long course (5-10 Years and more).Femara comes in tablets of 2.5 mg. For cancer, usual dosage is 2.5mg/day.If you're taking Femara for fertility treatment, your doctor may tell you to take either 2.5 mg or 5 mg of the drug, beginning on the third day of your period for five days.
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