Factory Cheap Hot MK2866 - Steroids Raw Powder AICAR Sarm Steroids Hormones CasNO.2627-69-2 for Muscle Bodybuilding – Hjtc

Melting point:214-215 °C

storage temp. −20°C

solubility H₂O: >10 mg/mL

form powder

color tan

Water Solubility Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml

λmax265nm(NaOH)(lit.)

Merck 14,16

InChIKeyRTRQQBHATOEIAF-UUOKFMHZSA-N

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.

AICAR’s principal mechanism of action is activation of AMPK (AMP-activated protein kinase.) Activating AMPK, therefore, causes the same cellular machinery (so to speak) to be turned on as if the cell were energy deprived, for example from intensive exercise, or from low caloric intake.

AICAR, at sufficient and quite substantial concentration, is effective at activating AMPK and inducing a cellular state as if exercise had been performed, or energy stores were low and fat therefore needed to be burned.

AICAR uses metabolic pathways to block certain enzymes, which allows for AMP-activated protein kinase. This can be explained to the layperson like this: once you take a substantial amount of AICAR, it tricks your body at a cellular level in to thinking that exercise has just been preformed. Since the body thinks it has just done a considerable amount of exercise, the energy cycle at the cellular level starts converting fuel sources, like fatty acids, to output the energy that was thought to have been spent during exercise.

This can have a direct effect on the level of endurance activity and the sustainability of that activity. Insulin sensitivity is also noted to be one action that AICAR produces, as the body will think it just went through a series of exercises. Interestingly, in animal studies with obese mice, AICAR showed all of the peptides benefits for obese diet induced mice, yet the healthy lean mice did not reap any of the benefits of insulin sensitivity or increase in glucose uptake. That being said, the application in bodybuilding does not seem very suitable, as these mechanisms are targeted for the out-of-shape and over-weight.

1,We only send the HIGHEST purity Steroids, Peptides, Research chemicals & Pharmaceuticals which are very popular in many countries like Kazakhstan ,Poland,Hungary ,Paraguay ,Uruguay,Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium,Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Serbia,Finland ,Italy , Estonia ,Thailand, Israel ,US, UK, Canada, Australia

2,Our prices are the best because of the discounts that we give to all our buyers. We give very good discounts which makes our prices outstanding in the market.

3,Genuine and 100% Guarantee on all orders you place. We Have the Best you will come across Online. We have adequate stock, and can arrange the delivery within 24hours when receiving the payment. Tracking number would be informed quickly after shipment.

4,We have the best customer service and excellent shipment ability. Contact us to have a full list of our products and price list.

5,Besides raw steroid powder and liquid,we offer hormone solution and formula.We can teach you how to make hormone solution on the site. Any visit to our lab is welcomed.

1. Any inquiries will be replied within 24 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.

Q1: Can I get some samples?
A: Sure, we offer free sample, you just need to pay the shipping cost.
 
Q2: How to make orders?
A: Please send inquiry to us, then we will do the offer. Payment via Western Union, Moneygram, Bank Account and Bitcoin. Then we will arrange shipping. After delivery we will offer tracking No..

Q3: Is the shipping 100% Guarantee?
A: Yes, we offer 100% Shipping Guarantee. If any seized parcel we will do resending. 

Q4: How to delivery?
A: Parcel will be shipped out in 3 working days after payment. Usually we use EMS, ePacket, Fedex, DHL, TNT and USA Domestic mixed shipping and so on. 
 
Q5: Is there any discount?
A:Yes. The price is negotiable. Just send us the items you need and the quantity. We will apply the best price and offer discount for you.
 
Q6: What is the Minimum order quantity?
A: Usually MOQ is 100g. But depends on the items and your requirements we also can do 10g, 20g, 30g or 50g.