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Follistatin 344 is a performance enhancer that has been recently gaining a lot of popularity. Simply put it is a protein. It is high in non-essential amino acid cysteine, but with attached carbohydrates. Its function is to bind and inhibit myostatin and other transforming growth factor peptides. These peptides prevent the body from putting on additional muscle fast. Suppress transforming growth factor peptides and you get a body that can put up an impressive amount of muscle, really fast. It’s no wonder that Follistatin 344 is gaining such a following in the bodybuilding circles.

        In recent times, bodybuilding and working out has gained a lot of popularity. With an acceptance in the mainstream, also comes a demand for performance enhancers and substances that will help you achieve the result that you desire. However, the fact that bodybuilding is an exact science is not very well known and performance enhancers are still looked at with suspicion.

       To put it simply, Myostatin inhibitors lower or completely stop the production of myostatin in your body. Pretty obvious right? Myostatin is a protein encoded by the MTSN gene. It is a growth differentiation factor and to put it simply, limits the amount of muscle one can build. It also places limits on how FAST you can build muscle. Without it, we could be gain upwards of 1 or 2lbs of muscle DAILY.

Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.

Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics, such as humans, rodents, and cows. Follistatin is high in the non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has carbohydrates attached to it.

Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.

 Follistatin-344 significantly increases muscle growth and muscle strength (by blocking the Moystatin activity) – it promotes hyperplasia (growth of new muscle cells) as well as active hypertrophy (increase in cell size).Follistatin-344 exhibits a potent anabolic activity (yet without concomitant androgenic activity). Taking Follistatin-344 results in muscular hyperplasia (growth of new muscle fibres) and active hypertrophy (increase in size of existing muscle fibres)Follistatin-344 has a strong ability to keep sportsmen in shape and maintain their muscle mass even when they stopped exercising.

       Follistatin-344 significantly increases performance Follistatin-344 exhibits a potent anti-aging effect, with a significant impact on rejuvenation of all body tissues.
       Follistatin-344 promotes body´s fat burning.

 Follistatin-344 significantly increases growth and strength of muscles by blocking Myostatin (GDF-8 – a protein inhibiting muscle growth). Follistatin-344 seems to be a very promising Myostatin inhibitor, possessing a sufficient safety profile.

        Follistatin-344 is also a perfect choice for those sportsmen who cannot exercise on a regular basis any longer or for those who stopped exercising, but they still want to stay in shape, having a huge muscle mass. It has been proved, that the less strenuous muscle load and the less physical activity is, the higher concentration of Myostatin is reached.

        Follistatin-344 (also known as activin-binding protein) is an autocrine glycoprotein encoded by the FST gene that is expressed in nearly all tissues. Its primary function in the body is bioneutralization of members of the TGF-β superfamily, with a particular focus on activin and paracrine hormones. Follistatin is a potent Moystatin inhibitor. An original Follistatin acted also as an activin inhibitor, which on the other hand stimulates the secretion of follicle-stimulating hormone – FSH (activin regulates the growth and differentiation of all cell types, including cells within sexual glands, pituitary gland and skeletal muscles). Therefore, scientists developed a particular Follistatin (Follisttain-344) that is derived from the original one and that is capable of blocking preferentially Moystatin activity.

Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids .

Follistatin works by binding to and inhibiting transforming growth factor-β (TGF-β) peptides such as myostatin which is responsible for regulating and limiting muscle growth. It’s also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.
In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function. [6] However, FSH levels that are too low can also negatively impact health and reproductive capabilities.

Whereas some myostatin inhibitors like Trichostatin A (TSA) require daily administration, increased levels of FS344 were observed up to 15 months after initial injection. [7][3] The lack of need for daily administration makes follistatin an attractive alternative for suppressing myostatin.

The recent increase in attention in the science community on follistatin and other myostatin inhibitors is primarily due to the desire to find an alternative means to treat muscle disorders; the most popular current option is androgen steroids which pose a number of side-effects and long-term health risks. At this point you might be wondering why follistatin use isn’t more widespread in bodybuilders and other athletes. In the next section we will examine the current research on follistatin and whether it builds muscle mass.

It’s also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.

In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function.

However, FSH levels that are too low can also negatively impact health and reproductive capabilities. Whereas some myostatin inhibitors like Trichostatin A (TSA) require daily administration, increased levels of FS344 were observed up to 15 months after initial injection. The lack of need for daily administration makes follistatin an attractive alternative for suppressing myostatin.

The recent increase in attention in the science community on follistatin and other myostatin inhibitors is primarily due to the desire to find an alternative means to treat muscle disorders; the most popular current option is androgen steroids which pose a number of side-effects and long-term health risks. At this point you might be wondering why follistatin use isn’t more widespread in bodybuilders and other athletes. In the next section we will examine the current research on follistatin and whether it builds muscle mass.

Follistatin is recommended for research, but people who have tried it themselves typically take injection 100 mcg/day of dose via injections for 10 to 30 days. Ideally, it can be taken every third day. People who have taken doses up to 200 mcg have not shown suffered from any adverse effects than the ones who have taken lower doses.

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