Bottom price Andarine S4 raw powder - 99% AICAR Steroids Raw Sarm Powder 100% Customs Pass with Perfect Stealth Package CasNO.2627-69-2 – Hjtc Detail:
AICAR (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in, but there are some amazing side effects. Interestingly, AICAR has been shown to protect against ischemic injury. This type of injury is directly related to the restriction of blood to tissues, which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive. This can lead to thrombosis, embolisms, and vasoconstriction. AICAR can be used as a stabilizing peptide for ischemic episodes, and it can allow for proper blood flow to the myocardium (heart). This function is very interesting, as AICAR could be fundamentally used to treat the heart muscle in the aftermath of a heart attack. This might reduce the possibility for ischemic injuries. Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide AICAR, which is a downside.
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulins-independent glucose uptake by skeletal muscle. Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.
| Item | Specification | Result |
| Appearance |
White powder |
Complies |
| Related substance (HPLC) |
Total impurity ≤0.5% Max single impurity ≤0.1% |
0.2% 0.06% |
| Odor | Characteristic | Complies |
| Assay | 99% | 99.8% |
| Sieve analysis | 100% pass 80 mesh | Complies |
|
Loss on Drying Residue on Ignition |
≤1.0% ≤1.0% |
0.12% 0.09% |
| Heavy Metal | <10ppm | Complies |
| As | <0.1ppm | 0.05ppm |
| Pb | <0.1ppm | 0.05ppm |
| Cd | <0.1ppm | 0.05ppm |
| Residual Solvents | <100ppm | Complies |
| Residual Pesticide | Negative | Complies |
| Microbiology | ||
| Total Plate Count | <1000cfu/g | Complies |
| Yeast & Mold | <100cfu/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
Sarms AICAR/ Acadesine powder help burn fat and sustain output in activity AICAR is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in.
Aicar (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/ inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
| Testosterone Steroid | ||
| No. | CAS NO | Name |
| 1 | CAS:58-22-0 | Testosterone base |
| 3 | CAS:76-43-7 | Fluoxymesterone Halotestin |
| 4 | CAS:2446-23-3 | 4-Chlorodehydromethyltestosterone(Oral turinabol) |
| 5 | CAS:1255-49-8 | Testosterone Phenylpropionate |
| 6 | CAS:57-85-2 | Testosterone Propionate |
| 7 | CAS:1045-69-8 | Testosterone acetate |
| 8 | CAS:315-37-7 | Testosterone enanthate |
| 9 | CAS:58-20-8 | Testosterone Cypionate |
| 10 | CAS:1424-00-6 | Mesterolone (Proviron) |
| 11 | CAS:5949-44-0 | Testosterone Undecanoate |
| 12 | CAS:15262-86-9 | Testosterone isocaproate |
| 13 | CAS:855-19-6 | Turinabol(4-Chlorotestosterone/Clostebol Acetate) |
| 14 | CAS: NO | Testosterone Sustanon 250/100 |
| 15 | CAS:5721-91-5 | Testosterone decanoate |
| 16 | CAS:58-18-4 | Methyltestosterone (17-methyltestosterone) |
| 17 | CAS:58-20-8 | 1-Test Cyp,Dihydroboldenone Cypionate |
| Boldenone Steroid | ||
| 17 | CAS:846-48-0 | Boldenone |
| 18 | CAS:13103-34-9 | Boldenone Undecylenate (Equipoise) |
| 19 | CAS:846-46-0 | Boldenone Acetate |
| 20 | CAS:13103-34-9 | Boldenone Propionate |
| 21 | CAS:106505-90-2 | Boldenone Cypionate |
| Trenbolone Steroid | ||
| 22 | CAS:10161-33-8 | Trenbolone base |
| 23 | CAS:10161-34-9 | Trenbolone acetate(Finaplix H/Revalor-H) |
| 24 | CAS:472-61-546 | Trenbolone enanthate(parabolan) |
| 25 | CAS:23454-33-3 | Trenbolone Hexahydrobenzyl Carbonate |
| Nandrolone Steroid | ||
| 26 | CAS:434-22-0 | Nandrolone |
| 27 | CAS:62-90-8 | Nandrolone Phenypropionate (NPP)/durabolin |
| 28 | CAS: 601-63-8 | Nandrolone cypionate |
| 29 | CAS:360-70-3 | Nandrolone decanoate(DECA)/ Deca durabolin |
| 30 | CAS: 862-89-5 | Nandrolone Undecylate |
| 31 | CAS: 7207-92-3 | Nandrolone propionate |
| Primobolan Steroid | ||
| 32 | CAS:434-05-9 | Methenolone Acetate(Primobolan) |
| 33 | CAS:303-42-4 | Methenolone enanthate (USAN) |
| 34 | CAS: 153-00-4 | Metenolone |
| 35 | CAS:3381-88-2 | Superdrol Powder/Methasterone (methyl-drostanolone) |
| 36 | CAS:521-12-0 | Drostanolone Propionate (Masteron) |
| 37 | CAS:472-61-145 | Drostanolone Enanthate(Masteron) |
| Anabolic Steroids | ||
| 38 | CAS:72-63-9 | Methandrostenolone (Dianabol, methandienone) |
| 39 | CAS:3704-09-4 | Mibolerone |
| 40 | CAS:965-93-5 | Methyltrienolone (Metribolone) |
| 41 | CAS:5197-58-0 | Methylstenbolone |
| 42 | CAS: 5630-53-5 | Tibolone |
| 43 | CAS:521-11-9 | Mestanolone |
| 44 | CAS:521-18-6 | Stanolone (androstanolone) |
| 45 | CAS:434-07-1 | Oxymetholone (Anadrol) |
| 46 | CAS:53-39-4 | Oxandrolone(Anavar) |
| 47 | CAS:10418-03-8 | stanozolol(Winstrol) |
| 48 | CAS:6157-87-5 | Trestolone acetate |
| 49 | CAS:853-23-6 | Dehydroisoandrosterone 3-acetate |
| 50 | CAS:53-43-0 | Dehydroepiandrosterone (DHEA) |
| 51 | CAS:481-29-8 | Epiandrosterone |
| 52 | CAS:566-19-8 | 7-Keto-dehydroepiandrosterone |
| 53 | CAS:76822-24-7 | 1-DHEA |
Other hot-selling steroids and peptides:
| Testosterone Acetate | Trenbolone Acetate | MGF |
| Testosterone Cypionate | Trenbolone Enanthate | PEG MGF |
| Testosterone Decanoate | Boldenone Acetate | CJC-1295 |
| Testosterone Enanthate | Boldenone undecylenate | CJC-1295 DAC |
| Testosterone Isocaproate | Boldenone Cypionate | PT-141 |
| Testosterone Phenylpropionate | Boldenone Propionate | Melanotan-1 |
| Testosterone Propionate | Nandrolone Decanoate | Melanotan-2 |
| Testosterone Undecanoate | Nandrolone phenylpropionate | GHRP-2 |
| Mesterone | Nandrolone undecylate | GHRP-6 |
| Testosterone Sustanon 250 | Nandrolone cypionate | Ipamorelin |
| Clostebol Acetate | Nandrolone propionate | Hexarelin |
| Methylandrostanolone | Methyltrienolone | Sermorelin |
| Methenolone Enanthate | Drostanolone Propionate | Oxytocin |
| Methenolone Acetate | Drostanolone Enanthate | TB500 |
| Anadrol | Stanolone | Fragment 176-191 |
| Anavar | Tadalafil | Triptorelin |
| Winstrol | Vardenafil | Tesamorelin |
| Clomifene citrate | Dianabol | Gonadorelin |
| Toremifene citrate | Tamoxifen Citrate | DSIP |
| Finasteride | hydrochloride | Selank |
| Benzocaine | Liothyronine sodium T3 | L-Carnitine |
1. By Express
——Suitable for under 50kg, Fast:3-7 days.
High cost; Door to door service. Easy to pick up the goods.
2. By Air
——Suitable for more than 50 kg, Fast:3-7 days,
High cost, airport to airport. professional broker needed.
3. By sea
——Suitable for more than 500kg. Slow: 5-45 days,
Low cost. Port to Port, professional broker needed.
Q1:How to confirm the Product Quality before placing orders?
A:free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
Q2:Can you give me a discount price?
A:Surely,It depend on your qty.Larger order can enjoy cheaper price.
Q3:When you ship my order?
A:Normally within 2 to 3 days after confirming your payment,because we need time to arrange Stealth Packing for 100% customs clearance.
Q4:Can you guarantee I can get my goods without any custom problem?
Yes, We have Reship Service.You can get your goods without any problem.
Q5:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,we will send you free goods for replacement or refund your loss.
Q6:Which kind of payment terms do you accept?
A:For any order,you can pay by Paypal,Bitcoin,T/T,Western Union or Money Gram.
Q7: How to contact with us?
A:We use email, whatsapp, wickr me, wechat,ect. so pls be free to contact me if you have any needs.
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We can normally fulfill our respected consumers with our great excellent, great value and good provider due to we're much more specialist and extra hard-working and do it in cost-effective way for Bottom price Andarine S4 raw powder - 99% AICAR Steroids Raw Sarm Powder 100% Customs Pass with Perfect Stealth Package CasNO.2627-69-2 – Hjtc, The product will supply to all over the world, such as: Indonesia, Philippines, Somalia, We look forward to hearing from you, whether you are a returning customer or a new one. We hope you will find what you are looking for here, if not, please contact us immediately. We pride ourselves on top notch customer service and response. Thank you for your business and support!
By Marcy Real from South Korea - 2018.03.03 13:09
The sales manager has a good English level and skilled professional knowledge, we have a good communication. He is a warm and cheerful man, we have a pleasant cooperation and we became very good friends in private.
By Leona from Russia - 2018.11.22 12:28