Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc

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Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc Detail:

Product Name: AICAR
Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR;Akt;mTOR;PI3K
Mol File: 2627-69-2.mol
 
AICAR Chemical Properties
Melting point 214-215 °C
storage temp. −20°C
solubility H2O: >10 mg/mL
form powder
color tan
Water Solubility Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
λmax 265nm(NaOH)(lit.)
Merck 14,16
InChIKey RTRQQBHATOEIAF-UUOKFMHZSA-N
CAS DataBase Reference 2627-69-2(CAS DataBase Reference)
EPA Substance Registry System 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)
 
Safety Information
Hazard Codes Xi,T
Risk Statements 36/37/38-61
Safety Statements 26-36-45-53
WGK Germany 3
TSCA Yes
 
MSDS Information
Provider Language
SigmaAldrich English
 
AICAR Usage And Synthesis
adenosine regulating agents Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate).
Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.
Chemical Properties Solid
Uses glucose uptake stimulant; AMPK activator
Uses AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Definition ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
Biological Activity Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

 

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

R-C (9)

Sarms Series
Ostarine / MK-2866 841205-47-8 MK-677 159752-10-0
Cardarine / GW-501516 317318-70-0 Andarine / S4 401900-40-1
Ligandrol / LGD-4033 1165910-22-4 RAD140 118237-47-0
SR9009 1379686-30-2 SR9011 1379686-29-9
YK11 431579-34-9 GW0742 317318-84-6
Aicar 2627-69-2 S-23 1010396-29-8
ACP105 899821-23-9 RU58841 154992-24-2

1,High quality with competitive price:
1)Standard: USP Standard
2)All Purity≥99%
3)We are manufacturer and can provide high quality products with factory price.

2,Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3,We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers’s requirement is our responsibility.
3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.

1. Any inquiries will be replied within 24 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.

研发中心5

Q1:How to confirm the Product Quality before placing orders?
A:free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
Q2:Can you give me a discount price?
A:Surely,It depend on your qty.Larger order can enjoy cheaper price.
Q3:When you ship my order?
A:Normally within 2 to 3 days after confirming your payment,because we need  time to arrange Stealth Packing for 100% customs clearance.
Q4:Can you guarantee I can get my goods without any custom problem?
Yes, We have Reship Service.You can get your goods without any problem.
Q5:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,we will send you free goods for replacement or refund your loss.
Q6:Which kind of payment terms do you accept?
A:For any order,you can pay by Paypal,Bitcoin,T/T,Western Union or Money Gram.
Q7: How to contact with us?
A:We use email, whatsapp, wickr me, wechat,ect. so pls be free to contact me if you have any needs.

 


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Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc detail pictures

Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc detail pictures

Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc detail pictures

Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc detail pictures

Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc detail pictures

Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc detail pictures


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Each individual member from our large performance revenue crew values customers' needs and company communication for Best Price for MK677 Powder - 99% Purity ACADESINE Raw Powder AICAR with Discreet Package CasNO.2627-69-2 – Hjtc, The product will supply to all over the world, such as: Ukraine, Australia, Thailand, Meanwhile, we're building up and consummating triangle market & strategic cooperation in order to achieve a multi-win trade supply chain to expand our market vertically and horizontally for a brighter prospects. development. Our philosophy is to create cost-effective products and solutions, promote perfect services, cooperate for long-term and mutual benefits, firm a in depth mode of excellent suppliers system and marketing agents, brand strategic cooperation sales system.
  • Staff is skilled, well-equipped, process is specification, products meet the requirements and delivery is guaranteed, a best partner!
    5 Stars By Mildred from Milan - 2017.03.28 16:34
    The sales person is professional and responsible, warm and polite, we had a pleasant conversation and no language barriers on communication.
    5 Stars By Kay from Egypt - 2017.12.31 14:53