Also called as GRF 1-29, Sermorelin is GHRH derivative that contains first, active 29 amino acids chain of GHRH that promote release of growth hormones from the pituitary. Sermorelin forms the shortest 1-29 fragment, yet completely functional fragment of GHRH. Increased levels of Sermorelin are linked with augmentation of lean muscular tissues, improved immunological functions, bone density and reduced adipose tissue fat.
Research studies have confirmed that 29 amino acids sequence are responsible for the pituitary gland stimulation. Hence, the GHRH analogue is designated as a potential diagnostic target for various growth hormone deficiency disorders. The molecular weight and formula is 3357.96 and C149H246N44O42S, respectively.
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Use sermorelin acetate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Sermorelin acetate is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using sermorelin acetate at home, carefully follow the injection procedures taught to you by your health care provider.
If sermorelin acetate contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
Do not shake sermorelin acetate when mixing.
Use sermorelin acetate immediately after mixing. Discard any unused medicine.
All other growth hormone therapy should be stopped 1 week before using sermorelin acetate. Contact your doctor or pharmacist if you have questions.
Keep this product, as well as syringes and needles, out of the reach of children and away from pets.
Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
If you miss a dose of sermorelin acetate, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Appearance | White or slightly yellowish powder | White powder | |
2 | Solubility | Soluble in water or 1% acetic acid at a concentration of 1mg/ml to give a clear, colorless solution | Conforms |
3 | Identity by HPLC | The retention is same with the reference substance | Conforms |
4 | Specific Optical Rotation | -80.0- -90.0°(c=0.5, 1%HAc) | -86.3° |
5 | Amino Acid Composition | ±10% of theoretical | Conforms |
6 | Peptide Purity (By HPLC) | ≥ 98.0% by area integration | 98.8% |
7 | Related Substance (By HPLC) | Total Impurities(%) ≤ 2.0% Largest Single Impurity (%) ≤ 1.0% | 1.2% 0.6% |
8 | Acetate Content | ≤ 15.0% | 12.1% |
9 | Water Content (Karl Fischer) | ≤ 5.0% | 4.5% |
10 | Peptide Content (N determination) | ≥ 80.0% | 83.3% |
11 | Bacterial Endotoxins | ≤5EU/mg |
Besides the obvious advantages of sermorelin detailed above, you may want to know how you can benefit from using this therapy. Perhaps the easiest way to understand the potential benefits of replacement therapy is to look at the symptoms of decline and the effect replacement has on those symptoms. These are detailed below:
1. Changes in Body Composition
Changes in body composition due to decreasing levels of are reflected by a decrease in lean body mass (muscle) and an increase in fat mass. Correcting levels has been shown to reverse this state by improving muscle mass and reducing fat.
2. Bone Mineral Density
Research indicates that deficiency in adults contributes to a reduction in bone density and therefore increased risk of osteoporosis. It has also been shown that replacement therapy for greater than 12 months results in improved bone mineral density and hence, lower risk of osteoporosis.
3. Muscle Strength
Due to changes in body composition detailed above, muscle strength is understandably compromised. As therapy corrects body composition and improves muscle mass, muscle strength also improves. The best results are gained after 12 months of therapy.
4. Joint Health
By improving bone mineral density and increasing muscle mass and strength, therapy can help to prevent joint deterioration that is a feature of arthritis. Optimal growth hormone levels are also essential for health of connective tissue such as the synovium found in joints.
5. Exercise Performance
Exercise performance is reduced in individuals with growth hormone deficiency. This appears to be partially due to reductions in bone density and muscle mass but also in part due to a reduction in oxygen uptake. therapy for 6 months has been shown to improve exercise performance by improving muscle mass and also oxygen uptake
6. Heart Health
There is evidence of a greater risk of heart disease in individuals with growth hormone deficiency and it has been hypothesized that this is due to a greater propensity to develop premature atherosclerosis (a build-up of plaque inside the arteries which increases risk of heart attack and stroke). Growth hormone deficiency also results in changes in heart size and function. These changes have been demonstrated to be reversed after 6 months therapy.
7. Metabolism
Growth hormone deficiency results in a reduced resting metabolism and replacement therapy reverses this decrease. therapy has also been shown to increase protein synthesis, increase fat oxidation, normalize carbohydrate metabolism and reduce LDL (bad) cholesterol. These favorable effects on metabolism may in part explain some of the other benefits of including improved hearth health and body composition.
8. Skin Thickness
A reduction in skin thickness and all-important skin collagen is another result of growth hormone deficiency. Both conditions are improved by therapy.
9 Immune Function
Although adults with growth hormone deficiency are not normally considered to have a compromised immune system, there is some evidence to suggest that therapy can help regulate immune function.
10. Libido
It has been demonstrated that people with growth hormone deficiency have more difficulty with sexual relationships and reportedly, lower energy levels. Many individuals have found an improvement in energy, libido and sexual performance following therapy, some men even claiming an improvement in problems with premature ejaculation.
11. Quality of Life
Reduced psychological well-being has been reported in individuals with growth hormone deficiency and replacement has resulted in improvements in mood, energy and general feelings of well-being.
1.Missing an injection
If an injection is delayed by 2-3 days, this should not make a big difference. But you should try to have your injections as regularly as possible.
2.Other medicines
Triptorelin can interact with other drugs. This includes medicines you can buy in a shop or chemist. Tell your doctor about any medicines you are taking, including ones you can buy for yourself, complementary therapies, vitamins and herbal drugs.
3.Medical treatment
If you need to go into hospital for any reason other than cancer, always tell the doctors and nurses that you are taking triptorelin. Explain you are taking hormonal therapy that no one should stop or restart without advice from your cancer doctor.
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1 | Clenbuterol | 40mcg*100/bottle |
2 | Clomid(Clomiphene) | 50mg*100/bottle |
3 | Letrozle(Femara) | 2.5mg*100/bottle |
4 | Halotestin(Fluoxymesterone) | 10mg*100/bottle |
5 | Dianabol(Methandrostenolone) | 10mg*100/bottle |
6 | Dianabol(Methandrostenolone) | 20mg*100/bottle |
7 | Dianabol(Methandrostenolone) | 50mg*100/bottle |
8 | Proviron(Mesterolone) | 10mg*100/bottle |
9 | Proviron(Mesterolone) | 25mg*100/bottle |
10 | Primobolan(Methenolone Acetate) | 10mg*100/bottle |
11 | Primobolan(Methenolone Acetate) | 25mg*100/bottle |
12 | Primobolan(Methenolone Acetate) | 50mg*100/bottle |
13 | Superdrol(Methasterone) | 10mg*100/bottle |
14 | T3(Liothytonine Sodium) | 25mcg*100/bottle |
15 | T3(Liothytonine Sodium) | 40mcg*100/bottle |
16 | T4 | 40mcg*100/bottle |
17 | Anavar(Oxandrolone) | 10mg*100/bottle |
18 | Anavar(Oxandrolone) | 25mg*100/bottle |
19 | Anavar(Oxandrolone) | 50mg*100/bottle |
20 | Anadrol(Oxymetholone) | 50mg*100/bottle |
21 | Winstrol(Stanozolol) | 10mg*100/bottle |
22 | Winstrol(Stanozolol) | 20mg*100/bottle |
23 | Winstrol(Stanozolol) | 50mg*100/bottle |
24 | Turinabol(Chlordehydromethyltestosterone) | 10mg*100/bottle |
25 | Turinabol(Chlordehydromethyltestosterone) | 25mg*100/bottle |
26 | Nolvadex(Tamoxifen) | 10mg*100/bottle |
27 | Nolvadex(Tamoxifen) | 20mg*100/bottle |
28 | Aromasin(Exemestane) | 25mg*100/bottle |
29 | Arimidex(Anastrozole) | 1mg*100/bottle |
30 | Viagra(Sildenafil) | 100mg*100/bottle |
31 | Cialis(Tadanafil) | 20mg*100/bottle |
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