18 Years Factory S23 Powder - Yk11 Sarm Myostatin Inhibitor Yk-11Raw Steroid Powder for Muscle Gaining CAS 431579-34-9 – Hjtc

What is YK11?
YK11 is the latest flavor of the month in the underground gray market bodybuilding supplement world.YK11 is a steroal molecule that has only been shown to have effects in cellular assays.This means that there are no published results in animals or humans as yet.Even so it has popped up for sale on the internet as an anabolic SARM or Selective Androgen Receptor Modulator. 

New age SARMs like LGD-4033 and Ostarine are non-stero,meaning that they do not have the typical four ring structure of classical androgens like Stero like Nan and perhaps tre can be considered to be SARMs since they convert through 5-alpha reduction to less potent androgens and in reasonable doses show more anabolic than androgenic effects.Stero has been turned into a bad word so for the most part,companies are developing non-stero SARMS.In reality,it makes little difference the shape of the molecule but rather what its effects are.

YK11 is stero.In fact, it looks a lot like.The two papers that are available show that YK11 can activate the androgen receptor but that it does so only partially.This results in an effect known as partial agonism.This means that YK11 can potentially displace stronger androgens while exerting a lower overall stimulating effect on the receptor.In fact the paper by Kanno et al demonstrates this effect by bathing cells in DHT alone or in DHT + YK11.Those cells that received both DHT and YK11 had less androgenic stimulation than with DHT alone.This is important since,in the presence of stronger androgens,YK11 will actually reduce androgen receptor stimulation.In the case of the prostate or hair follicle, this can be a good thing.In skeletal muscle, this will not be a good thing.

Since there have been no published results of the effects of YK11 in animals or humans,it is anyone’s guess what effects it will have.We do not even know if this molecule is orally bioavailable but since it is stero, there is a good chance that it may not be.Furthermore,since it is a partial agonist,there is no reason to believe that it would be anabolic in people with normal levels of test.Finally,we have no idea if this molecule is even remotely safe.Does it elevate liver enzymes,is it genotoxic or carcinogenic? New drugs go through a rigorous toxicological screening to ensure they are safe.To my knowledge, at least judging from the literature,none of this has been done with YK11.There are just too many unknowns with this compound to even consider using it.

SARMS or selective androgen receptor modulators are well-known for giving the same muscle growth results as anabolic steroids but without the negative side effects that comes with the latter. Japanese scientists are doing an experiment on a new SARM known as YK11 which is said to be the strongest amongst all, even more potent than classic steroids such as DHT. YK11 is believed to be a SARM and produce the effect of myostatin at the same time.

In 2011, Yuichiro Kanno of Toho University published the results of an initial study on YK11, confirming that the rare compound was a SARM.

YK11 attaches itself to the AR (androgen receptor), but only inducts methods that lead to the traditional side effects of androgens such as growth of body hair and prostate and enhanced aggression – to a restricted degree.

Most SARMS have quite limited androgenic side effects, but frequently only quite few anabolic effects when likened to testoste. But, this doesn’t occur for YK11 as reported in Biological and Pharmaceutical Bulletin in 2013.

Kanno tested C2C12 muscle cells and not lab animals or humans. It has been discovered that muscle cells produce more anabolic factors if exposed to 500 nmol (nanomoles) YK11 than if you expose the same muscle cells to 500 nmol DHT.

YK11 induces muscle cells to make more follistatin (more than DHT does) – a strong myostatin inhibitor. YK11 works through the androgen receptor.

With that said, YK11 can be as good as testoster in terms of muscle strengthening, but minus the detrimental side effects.

Benefit

SARM YK-11 is one of the most powerful S.A.R.M.S (Selective Androgen Receptor Modulator) on the market today. It is used to achieve Anabolic Steroid type results, but without the negative side effects and legality issues.This particular SARM “YK-11″ is for helping the user Gain Lean Muscle Tissue and Lose Fat simultaneously.

YK11 will have similar affects to DHT (possibly more potent) without the negatives of DHT. What this means is that the product will most likely be suppressive and require a post cycle, but not cycle support. It also won’t have androgenic side affects like hair loss, acne, etc. The increase in follistatin caused by YK11 will act as an antagonist to mystatin (it will block myostatin) as well as the anabolic growth properties of YK11.

YK11 shows a lot of promise as an apt anabolic SARM. With the muscle growth potential it brings, it’s as effective as anabolic steroids and prohormones without the unwanted side effects connected to the latter.SARM YK-11 is a powerful SARM supplement promoting massive lean muscle gains which is a great benefit for those wanting to have an aesthetic and shredded physique!

We expect YK11 to be more potent than SARM LGD in terms of overall growth and feel. At this time, we expect this to be the strongest SARM on the market at a regular dosing. While suppression can occur, we expect this product to have low androgenic properties and can be used by both men and women. From our experience with SARMs, we find there are less losses of on-cycle results than pro-hormones, although typically not as potent. We do expect this product to have similar results as a moderately dosed Halodrol, without the alpha-male/androgenic feelings while on it.

In direct comparison to to LGD-4033 as the reference for assay upon animal models of anabolism and androgenicity, YK-11 demonstrated higher efficacy withing anabolic parameters and lesser androgenicity at equivalent dosages.

It induces muscle cells to make more follistatin which is a strong myostatin inhibitor. Myostatin (also known as growth differentiation factor 8, is a myokine (protein) produced by muscle cells that acts on muscle cells to inhibit myogenesis. Myogenesis is muscle cell growth and differentiation. Research through the years show that when you block myostatin, it allows for significantly more muscle mass. So in research myostatin inhibitors are researched to find cures for muscle diseases.

Recommended maximum dose YK11 is require dosages of 2.0-5.0mg b.i.d. in males and 0.5mg-2mg b.i.d. in females to achieve optimal effects in humans for the noted indications.

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